Microscopy where no one can reach
Harnessing light propagation inside ultrathin fibers to unravel the next endomicroscopes generation
Light control through multimode fibers
Modendo develops ultrathin endomicroscopes that provide high-resolution optical imaging and photo-stimulation in currently inaccessible regions of the body. Modendo’s disruptive technology, developed by experts in the optics and neuroscience community, offers a new class of fundamentally less invasive optical imaging probes.
Modendo’s key technological innovation is in creating optical endoscopes that are truly minimally invasive (diameter ~100μm), digitally programmed, contain no moving parts, and most importantly, can penetrate tissue with minimal damage.
The underlying technology enables the transmission of high-resolution images in real time through an optical fiber probe that has a cross-area ~10 times smaller than the thinnest existing endoscopes. The Modendo team has shown record high-speed spatial modulation, the development of fast and robust algorithms, and the demonstration of fiber robustness to bending and perturbations. The team has pioneered research demonstrating multiple imaging modalities based on optical fibers including the first experiment in vivo.
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Caravaca-Aguirre, A.M. and Piestun, R., 2017. Single multimode fiber endoscope. Optics express, 25(3), pp.1656-1665.
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confocal_image [https://opg.optica.org/oe/fulltext.cfm?uri=oe-23-18-23845&id=324824###]
Loterie, D., Farahi, S., Papadopoulos, I., Goy, A., Psaltis, D. and Moser, C., 2015. Digital confocal microscopy through a multimode fiber. Optics express, 23(18), pp.23845-23858.
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two_photon [https://opg.optica.org/oe/fulltext.cfm?uri=oe-23-25-32158&id=333197#articleFigures]
Morales-Delgado, E.E., Psaltis, D. and Moser, C., 2015. Two-photon imaging through a multimode fiber. Optics express, 23(25), pp.32158-32170.
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photo_photo[https://pubs.aip.org/aip/apl/article/102/21/211106/24381]
Papadopoulos, I.N., Simandoux, O., Farahi, S., Pierre Huignard, J., Bossy, E., Psaltis, D. and Moser, C., 2013. Optical-resolution photoacoustic microscopy by use of a multimode fiber. Applied Physics Letters, 102(21).
Fluorescent beads (1μm diameter) embeded in agar gel imaged with Modendo’s endomicroscope
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image_photo [https://pubs.aip.org/aip/app/article/4/9/096103/1061457]
Caravaca-Aguirre, A.M., Singh, S., Labouesse, S., Baratta, M.V., Piestun, R. and Bossy, E., 2019. Hybrid photoacoustic-fluorescence microendoscopy through a multimode fiber using speckle illumination. Apl Photonics, 4(9).
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ablation_image [https://opg.optica.org/boe/fulltext.cfm?uri=boe-10-2-423&id=403636###]
Kakkava, E., Romito, M., Conkey, D.B., Loterie, D., Stankovic, K.M., Moser, C. and Psaltis, D., 2019. Selective femtosecond laser ablation via two-photon fluorescence imaging through a multimode fiber. Biomedical optics express, 10(2), pp.423-433.
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deep_learning [https://opg.optica.org/optica/fulltext.cfm?uri=optica-5-8-960&id=396110###]
Borhani, N., Kakkava, E., Moser, C. and Psaltis, D., 2018. Learning to see through multimode fibers. Optica, 5(8), pp.960-966.
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nonlinear [https://www.nature.com/articles/s41566-018-0167-7]
Tzang, O., Caravaca-Aguirre, A.M., Wagner, K. and Piestun, R., 2018. Adaptive wavefront shaping for controlling nonlinear multimode interactions in optical fibres. Nature Photonics, 12(6), pp.368-374.
News and events
Imaging Structure & Function in the Nervous System
Modendo is excited to be part of the upcoming 2025 Cold Spring Harbor course entitled “Imaging Structure & Function in the Nervous System” presenting our imaging technology and showing a full in-vivo demo of our latest system for calcium recording.
Contact us
Discover more about what makes ultrathin endomicroscopes unique, request for a demo or reach out to us with any questions