Research & Resources
See the work behind the technology.
Explore the publications, case studies, technical articles, white papers, imaging results, and demonstration videos advancing Modendo’s ultrathin-fiber platform.
From semiconductor inspection to neuroscience and medical innovation, this is where the methods, evidence, and collaborations come together.
Modendo In-Vivo Research Lab
Advancements in in vivo ultrathin endomicroscopy: Multi-site imaging, optogenetics, multispectral, dynamic imaging (GCaMP) and photoablation.
Laboratory of Applied Photonics Devices (LAPD)
Advancements in optical imaging- FLIM- and clinical applications within cancer.
FLIM imaging in Switzerland with Modendo’s prototype. Researchers will use this tehcnology to image ex vivo tissue from tumor biopsy in head and neck cancer.
Dan LaBarbera Research Lab
Fiber optic imaging of organoids in cell culture with a future focus on pharmaceutical testing and modeling in the context of personalized medicine.
In Vitro imaging of 3D-printed Osteosarcoma organoids. (A) Rep. image of a single organoid using a conventional confocal (E-Cadherin-488nm) (B) Organoids were 3D printed into 96-well plate, 1mm thick. (C) Rapid 3D imaging using Modendo probe.
Ana Clara Bobadilla Research Lab
Tracking and tuning of cells within deep drug-specific neuronal ensembles, employing multispectral imaging and complex time-locked behavioral cues.
Ultrathin endomicroscopy allows for the detection of unique neural ensembles in deep brain regions. TD-Tomato+ cells were tagged after drug exposure and co-infected with CA2+ reporters (not shown).
Imaging Structure and Function in the Nervous System course
Cell and circuit-specific dynamic recordings within the rodent brain.
Live imaging of GCaMP+ neurons as the fiber optic probe is lowered into the striatum. (Left) 100 micron diamater fiber optic probe moving in z(depth) during fluorescent imaging (488nm). (Right) Experiments performed at CSH 8/25. Multiple GCaMP sensors were tested as well as voltage sensors.
Alfredo Fontanini Research Lab
Minimally invasive imaging in the insular cortex and other subcortical areas involved in taste and reward.